Protective effects of safranal against subchronic thinner inhalation induced oxidative stress in rats

This study was carried out to determine the effects of subchronic thinner inhalation on oxidant− antioxidant balance,the relation between toxicity and oxidative stress, a possible protective effect α-lipoic acid against toxicationin rats. Sprague−Dawley rats were divided into 4 groups as follows: control (Gr. I), safranal II), III), andthinner+safranal Gr. IV). Each group consisted 10 rats, lasted for 8 weeks. After completing animalstudies malondialdehyde (MDA), reduced glutathione (GSH), toluol, 8OHdG (8 hydroxy 2 deoxyguanosine), proteinoxidation, nitric oxide metabolites (NOx), total capacity (TAC), oxidant (TOC), glucose, totalcholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, WBC, VLDL, RBC, HCT, Hb, aspartate amino transferase(AST), alanine transferase (ALT) levels determined from blood specimens Brain lungtissues also examined histopathologically. The data obtained statistically analyzed using SPSS,and both ANCOVA Bonferroni tests performed. P <0.05 accepted significant. resultsindicated that had balancing oriented complications in